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Phase 1 results announced for Skyhawk’s drug SKY-0515
Skyhawk Therapeutics shared results for SKY-0515, a drug designed to lower huntingtin. The drug appeared generally safe, with 60% reduction of huntingtin in blood at the highest dose tested. This data is an encouraging step as larger trials continue.
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Huntington’s Disease Community Advocacy Helps Land Critical FDA Meeting for AMT-130
⏱️5 min read |The Huntington’s disease community’s unprecedented mobilization helped secure a high-priority FDA meeting to discuss the path forward for AMT-130.
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Better Sleep, Better Function: New Study Links Sleep Quality to Clinical Outcomes in Huntington’s Disease
⏱️6 min read | Most people with HD report sleep problems, & new research suggests sleep quality is linked to many aspects of living with the disease. Wearables tracked people with HD for a year & revealed better sleep & strength training might help.
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Keeping up with HD research just got easier: Introducing the HDBuzz Trial Tracker
⏱️6 min read | Ever wonder when to expect the next update from a clinical trial for Huntington’s disease? The HDBuzz Trial Tracker puts future updates for HD trials on a clear timeline, with deeper explanations in our articles when you want them.
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Vaccines and Neurodegeneration: Lessons for Huntington’s Disease?
⏱️5 min read | Research suggests vaccines may reduce dementia risk by 20%. Infections cause inflammation and toxic byproducts that mitochondria normally clear. In HD, where mitochondria are impaired, vaccination is especially crucial.
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UniQure Secures Type A Meeting with FDA: What This Means for AMT-130
⏱️6 min read | UniQure secured a Type A FDA meeting, a high-priority discussion for urgent issues. Within 30 days, both sides will discuss what kind of data package might support the advancement of AMT-130 in the US.
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Putting Huntington’s disease medications to the test: results from the Neuro-HD trial
⏱️6 min read | A clinical trial, Neuro-HD, compared 3 common drugs for HD symptoms. The 1 year study found no “best” medication, but clear differences between treatments. The results support a personalised, symptom-by-symptom approach to HD treatment.
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HDBuzz Is Officially Independent: What This Means, and Why It Matters
We’re entering a new chapter. HDBuzz is now an independent organisation, strengthening our ability to report clearly, critically, and responsibly on HD research.
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2025: Year in Review
⏱️34 min read | As we usher in 2026, we look back on the landmark clinical trial findings, advancements in research, regulatory disappointments, and thunderous community unity that will define 2025 for the Huntington’s disease community.
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Break Up With Your CAGs: How Three Letters Could Change Huntington’s Disease
Scientists engineered stem cells with “interrupted” CAG repeats to break up the toxic stretch. This may stop expansion, and could improve problems in cells that model Huntington’s disease. This study suggests that DNA spelling can drive the disease.